Neurobiology of Disease -Synuclein Phosphorylation Enhances Eosinophilic Cytoplasmic Inclusion Formation in SH-SY5Y Cells
نویسندگان
چکیده
Wanli W. Smith,1 Russell L. Margolis,1 Xiaojie Li,2,6 Juan C. Troncoso,3 Michael K. Lee,3 Valina L. Dawson,2,4,5,6 Ted M. Dawson,2,4,6 Takashi Iwatsubo,7 and Christopher A. Ross1,2,4 Departments of 1Psychiatry, 2Neurology, 3Pathology, 4Neuroscience, and 5Physiology, and 6Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and 7Department of Neuropathology and Neuroscience, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
منابع مشابه
Serine 129 Phosphorylation of α-Synuclein Cross-Links with Tissue Transglutaminase to Form Lewy Body-Like Inclusion Bodies
Intraneuronal depositions of α-synuclein have been implicated in the pathogenesis of Parkinsons's disease (PD). Previous reports have identified the crosslinking between α-synuclein and tTG (tissue transglutaminase) in both PD patients and the cellular model. However, no researches have been conducted to further investigate their interaction in physiological conditions. To address this question...
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